Journal of Clinical Oncology  
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Oncology Glossary

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ZAP-70: protein involved in T-cell activation and differentiation signals. Early events in the activation of the T-cell receptor (CD3/TCR) is the activation of nonreceptor tyrosine kinases (eg, the Src family) leading to the phosphorylation of immunoreceptor, tyrosine-based activation motifs (ITAMs) in the cytoplasmic domains of the CD3/TCR ξ chains. The phosphorylation of ITAMs is responsible for the recruitment and activation of ξ-associated protein (ZAP) -70 via its SH2 domain, with subsequent recruitment and activation of other proteins.

ZD6126: an antivascular agent. ZD1626 is a phosphate prodrug of a colchicine derivative. After its conversion to N-acetylcolchinol, tubulin structure is disrupted as a consequence of microtubule depolymerization, which occurs when N-acetylcolchinol binds to tubulin at its colchicine-binding sites. By affecting endothelial functions important in the angiogenic process (eg, motility, invasion), agents that affect the integrity of microtubule dynamics act as antivascular agents.

zebularine: a cytidine analog and an inhibitor of DNA methlyation.

zinc finger: motifs found in DNA-binding proteins (eg, transcriptional factors). The consensus amino acid sequence of a zinc finger is Cys-X2-4-Cys-X3-Phe-X5-Leu-X2-His-X3-His (also known as C2H2) with the finger describing a loop of amino acids that protrude from the zinc binding site. It is not uncommon for transcriptional factors to have several zinc-finger domains. TFIIIA, for example, has nine tandem zinc-finger repeats.

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